Retinol-binding Protein 4 (RBP4) Protein Expression Is Increased in Omental Adipose Tissue of Severely Obese Patients
نویسندگان
چکیده
منابع مشابه
association of plasma retinol binding protein-4 (rbp4) and sonographic grading of fatty liver in obese iranian children
results rbp4 levels in obese children (19 482.9 ± 3 302.2 pg/ml) were higher than those found in the lean control group (14 295.68 ± 2 381.3 pg/ml) (p < 0.05). in the obese patients, rbp4 levels showed a significant correlation with the grade of fatty liver and bmi (p < 0.05). conclusions it was found that the level of rbp4 had a strong correlation with the severity of fatty liver. therefore, r...
متن کاملParallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects.
CONTEXT AND OBJECTIVE Adipokines are involved in the etiopathology of obesity-related disorders. Since the role of adipokine retinol-binding protein-4 (RBP4) in obesity remains uncertain and its relationship with other adipokines and inflammatory markers has not been examined in detail, we investigated the relationships of RBP4 mRNA expression and circulating protein levels with obesity, anthro...
متن کاملPioglitazone lowers serum retinol binding protein 4 by suppressing its expression in adipose tissue of obese rats.
BACKGROUND/AIMS Pioglitazone, a peroxisome proliferator-activated receptor γ activator, is clinically used to treat insulin resistance. However, the underlying mechanism of pioglitazone's action remains unclear. We investigated whether, and how, pioglitazone modulates serum level of retinol binding protein 4 (RBP4), an adipocytokine associated with obesity and insulin resistance. METHODS Insu...
متن کاملFenofibrate reduces serum retinol-binding protein-4 by suppressing its expression in adipose tissue.
Fenofibrate is a peroxisome proliferator-activated receptor-alpha (PPARalpha) activator that has been clinically used to treat dyslipidemia and insulin resistance. To better understand the molecular mechanisms underlying fenofibrate action, we investigated whether fenofibrate affects serum levels of retinol-binding protein-4 (RBP4), an adipocytokine that has recently been shown to link obesity ...
متن کاملMacrophages are novel sites of expression and regulation of retinol binding protein-4 (RBP4).
Obesity is linked to a low-level chronic inflammatory state that may contribute to the development of associated metabolic complications. Retinol-binding protein 4 (RBP4) is an adipokine associated with parameters of obesity including insulin resistance indices, body mass index, waist circumference, lipid profile, and recently, with circulating inflammatory factors. Due to the infiltration of a...
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ژورنال
عنوان ژورنال: Obesity
سال: 2010
ISSN: 1930-7381
DOI: 10.1038/oby.2009.328